› 4rso

X-ray diffraction
3.5Å resolution

The structure of the neurotropic AAVrh.8 viral vector

Released:
DOI: 10.2210/pdb4rso/pdb
PDB entry 4rso coloured by chain, front view.
PDB entry 4rso coloured by chain, side view.
PDB entry 4rso coloured by chain, top view.
Source organism: Non-human primate Adeno-associated virus
Primary publication:
Structure of neurotropic adeno-associated virus AAVrh.8.
Halder S, Van Vliet K, Smith JK, Duong TT, McKenna R, Wilson JM, Agbandje-McKenna M
J Struct Biol 192 21-36 (2015)
PMID: 26334681

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182336 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein Chain: A
Molecule details ›
Chain: A
Length: 736 amino acids
Theoretical weight: 81.45 KDa
Source organism: Non-human primate Adeno-associated virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q808Y3 (Residues: 1-736; Coverage: 100%)
Gene name: VP1
Sequence domains:
Structure domains: Parvovirus coat protein VP1/VP2

Ligands and Environments

3 bound ligands:
Ligand DA 1 x DA
Ligand NA 1 x NA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 355.5Å b: 358.9Å c: 371.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.219
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy.
Naso et al. (2017)
7 more

3 mentions without citation

Structure of neurotropic adeno-associated virus AAVrh.8.
Halder et al. (2015)
2 more