› 4rue

X-ray diffraction
3.3Å resolution

Human K2P4.1 (TRAAK) potassium channel, G124I mutant

Released:
DOI: 10.2210/pdb4rue/pdb
PDB entry 4rue coloured by chain, front view.
PDB entry 4rue coloured by chain, side view.
PDB entry 4rue coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.
Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL
Neuron 84 1198-212 (2014)
PMID: 25500157

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192705 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily K member 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 33.64 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9NYG8 (Residues: 1-274; Coverage: 70%)
Gene names: KCNK4, TRAAK
Sequence domains: Ion channel
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand K 6 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 87.49Å b: 118.697Å c: 128.701Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.293 0.292 0.323
Expression system: Komagataella pastoris

Quick links

Citations

14 review citations

Mechanically Activated Ion Channels.
Ranade et al. (2015)
13 more

8 mentions without citation

Structure of potassium channels.
Kuang et al. (2015)
7 more