› 4s0v

X-ray diffraction
2.5Å resolution

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant

Released:
DOI: 10.2210/pdb4s0v/pdb
PDB entry 4s0v coloured by chain, front view.
PDB entry 4s0v coloured by chain, side view.
PDB entry 4s0v coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Yin J, Mobarec JC, Kolb P, Rosenbaum DM
Nature 519 247-50 (2015)
PMID: 25533960

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129032 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orexin receptor type 2; Starch synthase catalytic domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 559 amino acids
Theoretical weight: 64.09 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43614 (Residues: 3-254, 294-388; Coverage: 78%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: HCRTR2, PAB2292
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand SUV 1 x SUV
Ligand OLA 1 x OLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 94.358Å b: 75.819Å c: 96.335Å
α: 90° β: 111.71° γ: 90°
R-values:
R R work R free
0.197 0.197 0.242
Expression system: Spodoptera frugiperda

Quick links

Citations

32 review citations

New paradigms in GPCR drug discovery.
Jacobson KA. (2015)
31 more

46 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
45 more