4s14

X-ray diffraction
3.54Å resolution

Crystal structure of the orphan nuclear receptor RORgamma ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dodecamer
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-155759 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor ROR-gamma Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 29.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51449 (Residues: 262-518; Coverage: 50%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor-interacting protein 1 Chain: C
Molecule details ›
Chain: C
Length: 12 amino acids
Theoretical weight: 1.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P48552 (Residues: 499-510; Coverage: 1%)
Gene name: NRIP1

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6322
Unit cell:
a: 158.179Å b: 158.179Å c: 129.801Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.187 0.219
Expression systems:
  • Escherichia coli
  • Not provided