› 4s1o

X-ray diffraction
1.84Å resolution

Structure of Mycobacterium tuberculosis NadD in complex with NADP

Released:
DOI: 10.2210/pdb4s1o/pdb
PDB entry 4s1o coloured by chain, front view.
PDB entry 4s1o coloured by chain, side view.
PDB entry 4s1o coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry author: Korotkov KV

Function and Biology Details

Reaction catalysed: 
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-161692 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable nicotinate-nucleotide adenylyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 22.35 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WJJ5 (Residues: 1-195; Coverage: 91%)
Gene names: MTCY428.26, Rv2421c, nadD
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

2 bound ligands:
Ligand NAP 2 x NAP
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 66.06Å b: 66.06Å c: 165.21Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.234
Expression system: Escherichia coli

Quick links