Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(36) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(36) + succinate + formaldehyde + CO(2)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Histone H3.1 and Lysine-specific demethylase 2A (preferred)
PDBe Complex ID:
PDB-CPX-157941 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Lysine-specific demethylase 2A
Molecule details ›
Chains: A, C
Length: 329 amino acids
Theoretical weight: 39.03 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Jumonji helical domain
Structure domains: Cupin
Length: 329 amino acids
Theoretical weight: 39.03 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P59997 (Residues: 36-364; Coverage: 28%)
Sequence domains: Jumonji helical domain
Structure domains: Cupin
Lysine-specific demethylase 2A
Molecule details ›
Chains: B, D
Length: 68 amino acids
Theoretical weight: 7.53 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Length: 68 amino acids
Theoretical weight: 7.53 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P59997 (Residues: 450-517; Coverage: 6%)
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Histone H3.1
Molecule details ›
Chains: E, F
Length: 15 amino acids
Theoretical weight: 1.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 15 amino acids
Theoretical weight: 1.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P68431 (Residues: 30-44; Coverage: 11%)
