› 4u9z

X-ray diffraction
1.8Å resolution

Structure of the alpha-tubulin acetyltransferase alpha-TAT1/Mec-17 in complex with CoA

Released:
DOI: 10.2210/pdb4u9z/pdb
PDB entry 4u9z coloured by chain, front view.
PDB entry 4u9z coloured by chain, side view.
PDB entry 4u9z coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yuzawa S, Sumimoto H

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-tubulin N-acetyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5SQI0 (Residues: 1-194; Coverage: 46%)
Gene names: ATAT1, C6orf134, MEC17, Nbla00487
Sequence domains: GNAT acetyltransferase, Mec-17
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand COA 1 x COA
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P21
Unit cell:
a: 43.645Å b: 34.329Å c: 64.226Å
α: 90° β: 103.03° γ: 90°
R-values:
R R work R free
0.218 0.216 0.258
Expression system: Escherichia coli BL21(DE3)

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