› 4uhx

X-ray diffraction
2.7Å resolution

Human aldehyde oxidase in complex with phthalazine and thioridazine

Released:
DOI: 10.2210/pdb4uhx/pdb
PDB entry 4uhx coloured by chain, front view.
PDB entry 4uhx coloured by chain, side view.
PDB entry 4uhx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase.
Coelho C, Foti A, Hartmann T, Santos-Silva T, Leimkühler S, Romão MJ
Nat Chem Biol 11 779-83 (2015)
PMID: 26322824

Function and Biology Details

Reaction catalysed: 
An aldehyde + H(2)O + O(2) = a carboxylate + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170321 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde oxidase Chain: A
Molecule details ›
Chain: A
Length: 1338 amino acids
Theoretical weight: 148.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06278 (Residues: 1-1338; Coverage: 100%)
Gene names: AO, AOX1
Sequence domains:

Ligands and Environments


Cofactor: Ligand MTE 1 x MTE

Cofactor: Ligand FAD 1 x FAD
6 bound ligands:
Ligand FES 2 x FES
Ligand MOS 1 x MOS
Ligand 4FT 1 x 4FT
Ligand LZU 1 x LZU
Ligand RTZ 1 x RTZ
Ligand MLI 2 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P42212
Unit cell:
a: 148.732Å b: 148.732Å c: 132.808Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.195 0.244
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Structure and function of mammalian aldehyde oxidases.
Terao et al. (2016)
8 more

6 mentions without citation

Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes.
Terao et al. (2020)
5 more