4uhz

X-ray diffraction
2.85Å resolution

Crystal structure of the human RGMB-BMP2 complex, crystal form 1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-146277 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bone morphogenetic protein 2 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12643 (Residues: 283-396; Coverage: 31%)
Gene names: BMP2, BMP2A
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Repulsive guidance molecule B Chain: B
Molecule details ›
Chain: B
Length: 96 amino acids
Theoretical weight: 10.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6NW40 (Residues: 52-136; Coverage: 22%)
Gene name: RGMB
Sequence domains: Repulsive guidance molecule (RGM) N-terminus

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I213
Unit cell:
a: 129.01Å b: 129.01Å c: 129.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.229
Expression systems:
  • Escherichia coli BL21(DE3)
  • Homo sapiens