› 4uq6

Electron Microscopy
12.8Å resolution

Electron density map of GluA2em in complex with LY451646 and glutamate

Released:
DOI: 10.2210/pdb4uq6/pdb
PDB entry 4uq6 coloured by chain, front view.
PDB entry 4uq6 coloured by chain, side view.
PDB entry 4uq6 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural mechanism of glutamate receptor activation and desensitization.
Meyerson JR, Kumar J, Chittori S, Rao P, Pierson J, Bartesaghi A, Mayer ML, Subramaniam S
Nature 514 328-34 (2014)
PMID: 25119039
Related structures: EMD-2684

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 826 amino acids
Theoretical weight: 92.63 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P19491 (Residues: 22-847; Coverage: 96%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GLU 4 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 12.8Å
Relevant EMDB volumes: EMD-2684
Expression system: Spodoptera frugiperda

Quick links

Citations

44 review citations

Structural Biology of the Major Facilitator Superfamily Transporters.
Yan N. (2015)
43 more

7 mentions without citation

Emerging structural insights into the function of ionotropic glutamate receptors.
Karakas et al. (2015)
6 more