› 4uqq

Electron Microscopy
7.6Å resolution

Electron density map of GluK2 desensitized state in complex with 2S,4R-4-methylglutamate

Released:
DOI: 10.2210/pdb4uqq/pdb
PDB entry 4uqq coloured by chain, front view.
PDB entry 4uqq coloured by chain, side view.
PDB entry 4uqq coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural mechanism of glutamate receptor activation and desensitization.
Meyerson JR, Kumar J, Chittori S, Rao P, Pierson J, Bartesaghi A, Mayer ML, Subramaniam S
Nature 514 328-34 (2014)
PMID: 25119039
Related structures: EMD-2685

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 882 amino acids
Theoretical weight: 99.55 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42260 (Residues: 32-908; Coverage: 100%)
Gene names: Glur6, Grik2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GLU 4 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.6Å
Relevant EMDB volumes: EMD-2685
Expression system: Spodoptera frugiperda

Quick links

Citations

44 review citations

Structural Biology of the Major Facilitator Superfamily Transporters.
Yan N. (2015)
43 more

6 mentions without citation

Emerging structural insights into the function of ionotropic glutamate receptors.
Karakas et al. (2015)
5 more