› 4uz0

X-ray diffraction
2.4Å resolution

Crystal Structure of apoptosis repressor with CARD (ARC)

Released:
DOI: 10.2210/pdb4uz0/pdb
PDB entry 4uz0 coloured by chain, front view.
PDB entry 4uz0 coloured by chain, side view.
PDB entry 4uz0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis.
Jang TH, Kim SH, Jeong JH, Kim S, Kim YG, Park HH
Sci Rep 5 9847 (2015)
PMID: 26038885

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130216 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleolar protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 95 amino acids
Theoretical weight: 10.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60936 (Residues: 1-95; Coverage: 46%)
Gene names: ARC, NOL3, NOP
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P65
Unit cell:
a: 99.351Å b: 99.351Å c: 51.102Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.17 0.2
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer.
Yu et al. (2019)
7 other articles

5 mentions without citation

Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond.
Ha et al. (2020)
4 more