› 4v6b

X-ray diffraction
2.85Å resolution

Crystal structure of human ferritin Phe167SerfsX26 mutant.

Released:
DOI: 10.2210/pdb4v6b/pdb
PDB entry 4v6b coloured by chain, front view.
PDB entry 4v6b coloured by chain, side view.
PDB entry 4v6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.
Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R
J Biol Chem 285 1950-6 (2010)
PMID: 19923220

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin Chains: AA, AB, AC, AD, AE, AF, AG, AH, AI, AJ, AK, AL, AM, AN, AO, AP, AQ, AR, AS, AT, AU, AV, AW, AX, Aa, Ab, Ac, Ad, Ae, Af, Ag, Ah, Ai, Aj, Ak, Al, Am, An, Ao, Ap, Aq, Ar, As, At, Au, Av, Aw, Ax, BA, BB, BC, BD, BE, BF, BG, BH, BI, BJ, BK, BL, BM, BN, BO, BP, BQ, BR, BS, BT, BU, BV, BW, BX, Ba, Bb, Bc, Bd, Be, Bf, Bg, Bh, Bi, Bj, Bk, Bl, Bm, Bn, Bo, Bp, Bq, Br, Bs, Bt, Bu, Bv, Bw, Bx, CA, CB, CC, CD, CE, CF, CG, CH, CI, CJ, CK, CL, CM, CN, CO, CP, CQ, CR, CS, CT, CU, CV, CW, CX, Ca, Cb, Cc, Cd, Ce, Cf, Cg, Ch, Ci, Cj, Ck, Cl, Cm, Cn, Co, Cp, Cq, Cr, Cs, Ct, Cu, Cv, Cw, Cx
Molecule details ›
Chains: AA, AB, AC, AD, AE, AF, AG, AH, AI, AJ, AK, AL, AM, AN, AO, AP, AQ, AR, AS, AT, AU, AV, AW, AX, Aa, Ab, Ac, Ad, Ae, Af, Ag, Ah, Ai, Aj, Ak, Al, Am, An, Ao, Ap, Aq, Ar, As, At, Au, Av, Aw, Ax, BA, BB, BC, BD, BE, BF, BG, BH, BI, BJ, BK, BL, BM, BN, BO, BP, BQ, BR, BS, BT, BU, BV, BW, BX, Ba, Bb, Bc, Bd, Be, Bf, Bg, Bh, Bi, Bj, Bk, Bl, Bm, Bn, Bo, Bp, Bq, Br, Bs, Bt, Bu, Bv, Bw, Bx, CA, CB, CC, CD, CE, CF, CG, CH, CI, CJ, CK, CL, CM, CN, CO, CP, CQ, CR, CS, CT, CU, CV, CW, CX, Ca, Cb, Cc, Cd, Ce, Cf, Cg, Ch, Ci, Cj, Ck, Cl, Cm, Cn, Co, Cp, Cq, Cr, Cs, Ct, Cu, Cv, Cw, Cx
Length: 192 amino acids
Theoretical weight: 21.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6S4P3 (Residues: 1-191; Coverage: 100%)
Gene name: FTL
Sequence domains: Ferritin-like domain

Ligands and Environments

1 bound ligand:
Ligand CA 48 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 212.34Å b: 236.94Å c: 249.71Å
α: 94.69° β: 115.06° γ: 114.96°
R-values:
R R work R free
0.249 0.249 0.291
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Iron metabolism in the CNS: implications for neurodegenerative diseases.
Rouault TA. (2013)
10 more

3 mentions without citation

Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration.
Muhoberac et al. (2019)
2 more