› 4v8l

Electron Microscopy
7.5Å resolution

Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase

Released:
DOI: 10.2210/pdb4v8l/pdb
PDB entry 4v8l coloured by chain, front view.
PDB entry 4v8l coloured by chain, side view.
PDB entry 4v8l coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis
Primary publication:
7.5-Å cryo-em structure of the mycobacterial fatty acid synthase.
Boehringer D, Ban N, Leibundgut M
J Mol Biol 425 841-9 (2013)
PMID: 23291528
Related structures: EMD-2238

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ketosynthase family 3 (KS3) domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 3089 amino acids
Theoretical weight: 325.76 KDa
Source organism: Mycolicibacterium smegmatis
UniProt:
  • Canonical: A0R1H7 (Residues: 1-3089; Coverage: 100%)
Gene name: MSMEG_4757
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand FMN 6 x FMN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.5Å
Relevant EMDB volumes: EMD-2238

Quick links

Citations

3 review citations

Using modern tools to probe the structure-function relationship of fatty acid synthases.
Finzel et al. (2015)
2 more

2 mentions without citation

Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM.
Bendre et al. (2021)
1 more