› 4v8m

Electron Microscopy
5.57Å resolution

High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome

Released:
DOI: 10.2210/pdb4v8m/pdb
PDB entry 4v8m coloured by chain, front view.
PDB entry 4v8m coloured by chain, side view.
PDB entry 4v8m coloured by chain, top view.
Source organisms:
Primary publication:
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome.
Hashem Y, des Georges A, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J
Nature 494 385-9 (2013)
PMID: 23395961
Related structures: EMD-2239

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 86-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112879 (preferred)
Entry contents:
76 distinct polypeptide molecules
10 distinct RNA molecules
Macromolecules (86 distinct):
Small ribosomal subunit protein eS1 Chain: A0
Molecule details ›
Chain: A0
Length: 256 amino acids
Theoretical weight: 29.48 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38BK6 (Residues: 1-256; Coverage: 100%)
Gene name: Tb10.70.3360
Sequence domains: Ribosomal S3Ae family
40S ribosomal protein S4 Chain: A1
Molecule details ›
Chain: A1
Length: 273 amino acids
Theoretical weight: 30.7 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q386F2 (Residues: 1-273; Coverage: 100%)
Gene names: Tb11.02.1085, Tb11.02.1090
Sequence domains:
Small ribosomal subunit protein uS7 domain-containing protein Chain: A2
Molecule details ›
Chain: A2
Length: 190 amino acids
Theoretical weight: 21.42 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q385D9 (Residues: 1-190; Coverage: 100%)
Gene name: Tb11.02.4170
Sequence domains: Ribosomal protein S7p/S5e
40S ribosomal protein S6 Chain: A3
Molecule details ›
Chain: A3
Length: 250 amino acids
Theoretical weight: 28.51 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CL9 (Residues: 1-250; Coverage: 100%)
Gene name: Tb10.100.0080
Sequence domains: Ribosomal protein S6e
40S ribosomal protein S7 Chain: A4
Molecule details ›
Chain: A4
Length: 202 amino acids
Theoretical weight: 23.89 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38FD9 (Residues: 1-202; Coverage: 100%)
Gene name: Tb09.160.2550
Sequence domains: Ribosomal protein S7e
40S ribosomal protein S8 Chain: A5
Molecule details ›
Chain: A5
Length: 220 amino acids
Theoretical weight: 25 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57YL6 (Residues: 1-220; Coverage: 100%)
Gene names: Tb08.11J15.560, Tb08.11J15.570, Tb927.8.6150, Tb927.8.6160
Sequence domains: Ribosomal protein S8e
40S ribosomal protein S9, putative Chain: A6
Molecule details ›
Chain: A6
Length: 190 amino acids
Theoretical weight: 22.1 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57VP3 (Residues: 1-190; Coverage: 100%)
Gene names: Tb08.29O4.180, Tb10.70.1380, Tb927.8.1110
Sequence domains:
Guanine nucleotide-binding protein beta subunit-like protein Chain: A7
Molecule details ›
Chain: A7
Length: 318 amino acids
Theoretical weight: 34.73 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q383E1 (Residues: 1-318; Coverage: 100%)
Gene names: Tb11.01.3170, Tb11.01.3180
Sequence domains: WD domain, G-beta repeat
RIBOSOMAL PROTEIN S29, PUTATIVE Chain: A8
Molecule details ›
Chain: A8
Length: 57 amino acids
Theoretical weight: 6.68 KDa
Source organism: Trypanosoma brucei brucei TREU927
Ubiquitin-ribosomal protein eL40 fusion protein Chain: A9
Molecule details ›
Chain: A9
Length: 153 amino acids
Theoretical weight: 16.94 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57WI3 (Residues: 1-153; Coverage: 100%)
Gene names: Tb07.28B13.250, Tb927.7.3680
Sequence domains:
Small ribosomal subunit protein uS2 Chain: AC
Molecule details ›
Chain: AC
Length: 277 amino acids
Theoretical weight: 31.4 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q383I8 (Residues: 1-277; Coverage: 100%)
Gene name: Tb11.01.2680
Sequence domains: Ribosomal protein S2
Plectin/eS10 N-terminal domain-containing protein Chain: AD
Molecule details ›
Chain: AD
Length: 172 amino acids
Theoretical weight: 19.32 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38B66 (Residues: 1-172; Coverage: 100%)
Gene name: Tb10.70.1670
Sequence domains: Plectin/S10 domain
Small ribosomal subunit protein uS17 N-terminal domain-containing protein Chain: AE
Molecule details ›
Chain: AE
Length: 174 amino acids
Theoretical weight: 20.13 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CI4 (Residues: 1-174; Coverage: 100%)
Gene name: Tb10.70.7695
Sequence domains:
40S ribosomal protein S12 Chain: AF
Molecule details ›
Chain: AF
Length: 144 amino acids
Theoretical weight: 15.89 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q385Y8 (Residues: 1-144; Coverage: 100%)
Gene name: Tb11.02.1830
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein uS15 N-terminal domain-containing protein Chain: AG
Molecule details ›
Chain: AG
Length: 151 amino acids
Theoretical weight: 17.35 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q586C2 (Residues: 1-151; Coverage: 100%)
Gene names: 1F7.325, Tb10.61.1390, Tb927.2.5910
Sequence domains:
40s ribosomal protein S14, putative Chain: AH
Molecule details ›
Chain: AH
Length: 144 amino acids
Theoretical weight: 15.54 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q4FKG9 (Residues: 1-144; Coverage: 100%)
Gene names: Tb06.30P15.510, Tb11.0290, Tb11.0390, Tb927.6.4980
Sequence domains: Ribosomal protein S11
40S ribosomal protein S15, putative Chain: AI
Molecule details ›
Chain: AI
Length: 152 amino acids
Theoretical weight: 17.51 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57XN7 (Residues: 1-152; Coverage: 100%)
Gene names: Tb07.22O10.320, Tb07.22O10.360, Tb927.7.2340, Tb927.7.2370
Sequence domains: Ribosomal protein S19
40S ribosomal protein S15a, putative Chain: AJ
Molecule details ›
Chain: AJ
Length: 130 amino acids
Theoretical weight: 14.67 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q580K6 (Residues: 1-130; Coverage: 100%)
Gene names: Tb03.26J7.620, Tb11.02.4000, Tb927.3.4360
Sequence domains: Ribosomal protein S8
40S ribosomal protein S16, putative Chain: AK
Molecule details ›
Chain: AK
Length: 149 amino acids
Theoretical weight: 17.03 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57VV0 (Residues: 1-149; Coverage: 100%)
Gene names: Tb07.29K4.40, Tb07.29K4.50, Tb927.7.1040, Tb927.7.1050
Sequence domains: Ribosomal protein S9/S16
40S ribosomal protein S17, putative Chain: AL
Molecule details ›
Chain: AL
Length: 142 amino acids
Theoretical weight: 16.26 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q382Z8 (Residues: 1-142; Coverage: 100%)
Gene names: Tb11.01.3675, Tb11.01.3676
Sequence domains: Ribosomal S17
40S ribosomal protein S18, putative Chain: AM
Molecule details ›
Chain: AM
Length: 153 amino acids
Theoretical weight: 17.55 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38B69 (Residues: 1-153; Coverage: 100%)
Gene names: Tb10.70.1730, Tb10.70.1740
Sequence domains: Ribosomal protein S13/S18
Ribosomal protein S19, putative Chain: AO
Molecule details ›
Chain: AO
Length: 167 amino acids
Theoretical weight: 18.89 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q583K7 (Residues: 1-167; Coverage: 100%)
Gene names: Tb04.29M18.160, Tb927.4.1860
Sequence domains: Ribosomal protein S19e
S5 DRBM domain-containing protein Chain: AP
Molecule details ›
Chain: AP
Length: 266 amino acids
Theoretical weight: 28.69 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q388D3 (Residues: 1-266; Coverage: 100%)
Gene names: Tb10.61.1960, Tb10.61.2070
Sequence domains:
RIBOSOMAL PROTEIN S20, PUTATIVE Chain: AQ
Molecule details ›
Chain: AQ
Length: 117 amino acids
Theoretical weight: 13.25 KDa
Source organism: Trypanosoma brucei brucei TREU927
40S ribosomal protein S21, putative Chain: AR
Molecule details ›
Chain: AR
Length: 194 amino acids
Theoretical weight: 21.16 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q385B8 (Residues: 1-194; Coverage: 100%)
Gene name: Tb11.02.4360
Sequence domains: Ribosomal protein S21e
40S ribosomal protein S23, putative Chain: AS
Molecule details ›
Chain: AS
Length: 143 amino acids
Theoretical weight: 15.96 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CD1 (Residues: 1-143; Coverage: 100%)
Gene names: Tb10.70.7020, Tb10.70.7030
Sequence domains: Ribosomal protein S12/S23
40S ribosomal protein S24 Chain: AT
Molecule details ›
Chain: AT
Length: 137 amino acids
Theoretical weight: 15.72 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38AM9 (Residues: 1-137; Coverage: 100%)
Gene names: Tb10.6k15.3340, Tb10.6k15.3350
Sequence domains: Ribosomal protein S24e
40S ribosomal protein S25 Chain: AU
Molecule details ›
Chain: AU
Length: 113 amino acids
Theoretical weight: 12.59 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57XX0 (Residues: 1-113; Coverage: 100%)
Gene names: Tb03.1J15.510, Tb10.70.4800, Tb927.3.1370
Sequence domains: S25 ribosomal protein
40S ribosomal protein S26 Chain: AV
Molecule details ›
Chain: AV
Length: 111 amino acids
Theoretical weight: 12.84 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q384J9 (Residues: 1-111; Coverage: 100%)
Gene name: Tb11.01.0355
Sequence domains: Ribosomal protein S26e
40S ribosomal protein S27, putative Chain: AW
Molecule details ›
Chain: AW
Length: 86 amino acids
Theoretical weight: 9.65 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q383V7 (Residues: 1-86; Coverage: 100%)
Gene name: Tb11.01.1475
Sequence domains: Ribosomal protein S27
40S ribosomal protein S3 Chain: AX
Molecule details ›
Chain: AX
Length: 214 amino acids
Theoretical weight: 24.26 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q389I7 (Residues: 1-214; Coverage: 100%)
Gene name: Tb10.26.0370
Sequence domains:
40S ribosomal protein S30 Chain: AY
Molecule details ›
Chain: AY
Length: 66 amino acids
Theoretical weight: 7.45 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q584U5 (Residues: 1-66; Coverage: 100%)
Gene names: Tb06.4M18.360, Tb927.6.2110
Sequence domains: Ribosomal protein S30
40S ribosomal protein S33, putative Chain: AZ
Molecule details ›
Chain: AZ
Length: 103 amino acids
Theoretical weight: 11.19 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57U30 (Residues: 1-103; Coverage: 100%)
Gene names: Tb07.8P12.310, Tb07.8P12.320, Tb927.7.230, Tb927.7.240
Sequence domains: Ribosomal protein S28e
Large ribosomal subunit protein eL18 Chain: BI
Molecule details ›
Chain: BI
Length: 193 amino acids
Theoretical weight: 21.93 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: P50885 (Residues: 1-193; Coverage: 100%)
Gene names: RPL18-A, RPL18-B, Tb10.6k15.0410, Tb11.02.1840
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
Ribosomal protein Chain: BJ
Molecule details ›
Chain: BJ
Length: 214 amino acids
Theoretical weight: 24.64 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q383V8 (Residues: 1-214; Coverage: 100%)
Gene names: Tb10.05.0220, Tb11.01.1470
Sequence domains: Ribosomal protein L1p/L10e family
60S ribosomal protein L10, putative Chain: BK
Molecule details ›
Chain: BK
Length: 213 amino acids
Theoretical weight: 24.79 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38EC5 (Residues: 1-213; Coverage: 100%)
Gene names: Tb09.211.0110, Tb09.211.0340
Sequence domains: Ribosomal protein L16p/L10e
60S ribosomal protein L11, putative Chain: BL
Molecule details ›
Chain: BL
Length: 194 amino acids
Theoretical weight: 22.42 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38EI9 (Residues: 1-194; Coverage: 100%)
Gene names: Tb09.160.5580, Tb09.160.5590
Sequence domains:
60S ribosomal protein L12, putative Chain: BM
Molecule details ›
Chain: BM
Length: 164 amino acids
Theoretical weight: 17.59 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57YK4 (Residues: 1-164; Coverage: 100%)
Gene names: Tb08.11J15.820, Tb927.8.6030
Sequence domains:
60S ribosomal protein L13 Chain: BN
Molecule details ›
Chain: BN
Length: 218 amino acids
Theoretical weight: 25.49 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57V54 (Residues: 1-218; Coverage: 100%)
Gene names: Tb03.3K10.390, Tb927.3.3320
Sequence domains: Ribosomal protein L13e
60S ribosomal protein L13a, putative Chain: BO
Molecule details ›
Chain: BO
Length: 222 amino acids
Theoretical weight: 25.78 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q585J5 (Residues: 1-222; Coverage: 100%)
Gene names: Tb04.26G5.360, Tb05.30H13.890, Tb927.4.3550, Tb927.5.1610
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein eL14 Chain: BP
Molecule details ›
Chain: BP
Length: 189 amino acids
Theoretical weight: 21.74 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: P55842 (Residues: 1-189; Coverage: 100%)
Sequence domains:
Ribosomal protein L15 Chain: BQ
Molecule details ›
Chain: BQ
Length: 221 amino acids
Theoretical weight: 26.46 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CY7 (Residues: 1-221; Coverage: 100%)
Gene name: Tb09.244.2720
Sequence domains: Ribosomal L15
60S ribosomal protein L17, putative Chain: BR
Molecule details ›
Chain: BR
Length: 166 amino acids
Theoretical weight: 19.15 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q385T6 (Residues: 1-166; Coverage: 100%)
Gene names: Tb10.61.2090, Tb11.02.2430
Sequence domains: Ribosomal protein L22p/L17e
60S ribosomal protein L18a Chain: BS
Molecule details ›
Chain: BS
Length: 179 amino acids
Theoretical weight: 20.95 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q382C4 (Residues: 1-179; Coverage: 100%)
Gene names: Tb10.70.3510, Tb11.01.5720
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL19 domain-containing protein Chain: BT
Molecule details ›
Chain: BT
Length: 260 amino acids
Theoretical weight: 29.49 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57ZI7 (Residues: 1-260; Coverage: 100%)
Gene names: Tb07.27E10.170, Tb07.27E10.210, Tb927.7.5000, Tb927.7.5020
Sequence domains: Ribosomal protein L19e
60S ribosomal protein L21E, putative Chain: BU
Molecule details ›
Chain: BU
Length: 159 amino acids
Theoretical weight: 18.04 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q4FKD4 (Residues: 1-159; Coverage: 100%)
Gene names: Tb11.0880, Tb11.50.0005
Sequence domains: Ribosomal protein L21e
Large ribosomal subunit protein eL22 Chain: BV
Molecule details ›
Chain: BV
Length: 130 amino acids
Theoretical weight: 15.29 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q383R3 (Residues: 1-130; Coverage: 100%)
Gene name: Tb11.01.1920
Sequence domains: Ribosomal L22e protein family
60S ribosomal protein L23, putative Chain: BW
Molecule details ›
Chain: BW
Length: 139 amino acids
Theoretical weight: 14.99 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38DP2 (Residues: 1-139; Coverage: 100%)
Gene names: Tb09.211.2630, Tb09.211.2640
Sequence domains: Ribosomal protein L14p/L23e
60S ribosomal protein L23a Chain: BX
Molecule details ›
Chain: BX
Length: 164 amino acids
Theoretical weight: 18.21 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57ZH2 (Residues: 1-164; Coverage: 100%)
Gene names: Tb07.27E10.400, Tb927.7.5170
Sequence domains: Ribosomal protein L23
60S ribosomal protein L24, putative Chain: BY
Molecule details ›
Chain: BY
Length: 125 amino acids
Theoretical weight: 14.63 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38B56 (Residues: 1-125; Coverage: 100%)
Gene name: Tb10.70.1540
Sequence domains: Ribosomal protein L24e
KOW domain-containing protein Chain: BZ
Molecule details ›
Chain: BZ
Length: 143 amino acids
Theoretical weight: 16.5 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38D25 (Residues: 1-143; Coverage: 100%)
Gene name: Tb09.211.4850
Sequence domains:
KOW domain-containing protein Chain: Ba
Molecule details ›
Chain: Ba
Length: 133 amino acids
Theoretical weight: 15.62 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q381J6 (Residues: 1-133; Coverage: 100%)
Gene names: Tb11.01.7535, Tb11.01.7545
Sequence domains:
Large ribosomal subunit protein uL15/eL18 domain-containing protein Chain: Bb
Molecule details ›
Chain: Bb
Length: 145 amino acids
Theoretical weight: 16.31 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38DN9 (Residues: 1-145; Coverage: 100%)
Gene names: Tb09.211.2650, Tb09.v1.0640
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL28 Chain: Bc
Molecule details ›
Chain: Bc
Length: 146 amino acids
Theoretical weight: 16.9 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q385E9 (Residues: 1-146; Coverage: 100%)
Gene names: Tb11.02.4050, Tb11.02.4070
Sequence domains: Ribosomal L28e protein family
60S ribosomal protein L29 Chain: Bd
Molecule details ›
Chain: Bd
Length: 71 amino acids
Theoretical weight: 8.24 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q383S6 (Residues: 1-71; Coverage: 100%)
Gene name: Tb11.01.1790
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein uL2 C-terminal domain-containing protein Chain: Be
Molecule details ›
Chain: Be
Length: 260 amino acids
Theoretical weight: 28.37 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57W56 (Residues: 1-260; Coverage: 100%)
Gene names: Tb05.28F8.80, Tb11.01.7960, Tb927.5.1110
Sequence domains:
Ribosomal protein L3, mitochondrial, putative Chain: Bf
Molecule details ›
Chain: Bf
Length: 429 amino acids
Theoretical weight: 48.8 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q581Q1 (Residues: 1-429; Coverage: 100%)
Gene names: Tb04.2L9.1340, Tb927.4.1800
Sequence domains: Ribosomal protein L3
Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein Chain: Bg
Molecule details ›
Chain: Bg
Length: 105 amino acids
Theoretical weight: 11.53 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38BI9 (Residues: 1-105; Coverage: 100%)
Gene name: Tb10.70.3170
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
60S ribosomal subunit protein L31, putative Chain: Bh
Molecule details ›
Chain: Bh
Length: 188 amino acids
Theoretical weight: 21.75 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38DH8 (Residues: 1-188; Coverage: 100%)
Gene names: Tb09.211.3270, Tb09.211.3280
Sequence domains: Ribosomal protein L31e
60S ribosomal protein L32, putative Chain: Bi
Molecule details ›
Chain: Bi
Length: 132 amino acids
Theoretical weight: 15.43 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CL1 (Residues: 1-132; Coverage: 100%)
Gene name: Tb10.100.0155
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL34 Chain: Bj
Molecule details ›
Chain: Bj
Length: 170 amino acids
Theoretical weight: 19.4 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q383V6 (Residues: 1-170; Coverage: 100%)
Gene name: Tb11.01.1480
Sequence domains: Ribosomal protein L34e
60S ribosomal protein L35, putative Chain: Bk
Molecule details ›
Chain: Bk
Length: 127 amino acids
Theoretical weight: 15.19 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38FW8 (Residues: 1-127; Coverage: 100%)
Gene names: Tb09.160.0700, Tb09.160.0710
Sequence domains: Ribosomal L29 protein
60S ribosomal protein L35A, putative Chain: Bl
Molecule details ›
Chain: Bl
Length: 149 amino acids
Theoretical weight: 17.06 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q584G9 (Residues: 1-149; Coverage: 100%)
Gene names: Tb04.1H19.150, Tb927.4.2180
Sequence domains: Ribosomal protein L35Ae
Ribosomal protein L36, putative Chain: Bm
Molecule details ›
Chain: Bm
Length: 109 amino acids
Theoretical weight: 12.49 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CY6 (Residues: 1-109; Coverage: 100%)
Gene name: Tb09.244.2725
Sequence domains: Ribosomal protein L36e
Ribosomal protein L37 Chain: Bn
Molecule details ›
Chain: Bn
Length: 84 amino acids
Theoretical weight: 10.13 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q386L1 (Residues: 1-84; Coverage: 100%)
Gene names: Tb09.211.0865, Tb11.02.0500
Sequence domains: Ribosomal protein L37e
60S ribosomal proteins L37, putative Chain: Bo
Molecule details ›
Chain: Bo
Length: 93 amino acids
Theoretical weight: 10.48 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38AW9 (Residues: 1-93; Coverage: 100%)
Gene names: Tb10.100.0110, Tb10.70.0465
Sequence domains: Ribosomal L37ae protein family
60S ribosomal protein L38, putative Chain: Bp
Molecule details ›
Chain: Bp
Length: 82 amino acids
Theoretical weight: 9.53 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38FV6 (Residues: 1-82; Coverage: 100%)
Gene name: Tb09.160.0815
Sequence domains: Ribosomal L38e protein family
60S ribosomal protein L39, putative Chain: Bq
Molecule details ›
Chain: Bq
Length: 51 amino acids
Theoretical weight: 6.57 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57UJ8 (Residues: 1-51; Coverage: 100%)
Gene names: Tb08.5H5.400, Tb927.8.5260
Sequence domains: Ribosomal L39 protein
Large ribosomal subunit protein uL4 C-terminal domain-containing protein Chain: Br
Molecule details ›
Chain: Br
Length: 374 amino acids
Theoretical weight: 41.94 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q582N2 (Residues: 1-374; Coverage: 100%)
Gene names: Tb03.48K5.830, Tb927.3.5050
Sequence domains:
Ubiquitin-ribosomal protein eL40 fusion protein Chain: Bs
Molecule details ›
Chain: Bs
Length: 128 amino acids
Theoretical weight: 14.69 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: P21899 (Residues: 1-128; Coverage: 100%)
Sequence domains:
60S ribosomal protein L44 Chain: Bt
Molecule details ›
Chain: Bt
Length: 106 amino acids
Theoretical weight: 12.49 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: D7SG81 (Residues: 1-106; Coverage: 100%)
Gene names: 36E18.45, Tb11.02.0740, Tb927.2.6090
Sequence domains: Ribosomal protein L44
Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein Chain: Bu
Molecule details ›
Chain: Bu
Length: 308 amino acids
Theoretical weight: 34.71 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CY8 (Residues: 1-308; Coverage: 100%)
Gene names: Tb09.244.2730, Tb09.244.2740
Sequence domains:
60S ribosomal protein L6, putative Chain: Bv
Molecule details ›
Chain: Bv
Length: 192 amino acids
Theoretical weight: 21.23 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q389K1 (Residues: 1-192; Coverage: 100%)
Gene name: Tb10.26.0560
Sequence domains: Ribosomal protein L6e
60S ribosomal protein L7, putative Chain: Bw
Molecule details ›
Chain: Bw
Length: 257 amino acids
Theoretical weight: 29.42 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57V35 (Residues: 1-257; Coverage: 100%)
Gene names: Tb07.43M14.130, Tb07.43M14.140, Tb927.7.1740, Tb927.7.1750
Sequence domains:
60S ribosomal protein L7a Chain: Bx
Molecule details ›
Chain: Bx
Length: 276 amino acids
Theoretical weight: 30.95 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q57VM1 (Residues: 1-276; Coverage: 100%)
Gene names: Tb08.29O4.580, Tb08.29O4.590, Tb927.8.1330, Tb927.8.1340
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 alpha-beta domain-containing protein Chain: By
Molecule details ›
Chain: By
Length: 189 amino acids
Theoretical weight: 21.9 KDa
Source organism: Trypanosoma brucei brucei TREU927
UniProt:
  • Canonical: Q38CD0 (Residues: 1-189; Coverage: 100%)
Gene name: Tb10.70.7010
Sequence domains: Ribosomal protein L6
28S ribosomal RNA Chain: BA
Molecule details ›
Chain: BA
Length: 1847 nucleotides
Theoretical weight: 595.8 KDa
Source organism: Trypanosoma brucei
Sequence domains: Eukaryotic large subunit ribosomal RNA
28S ribosomal RNA Chain: BB
Molecule details ›
Chain: BB
Length: 1465 nucleotides
Theoretical weight: 471.45 KDa
Source organism: Trypanosoma brucei
Sequence domains: Eukaryotic large subunit ribosomal RNA
5.8S ribosomal RNA Chain: BC
Molecule details ›
Chain: BC
Length: 169 nucleotides
Theoretical weight: 54.22 KDa
Source organism: Trypanosoma brucei
Sequence domains: 5.8S ribosomal RNA
5S ribosomal RNA Chain: BD
Molecule details ›
Chain: BD
Length: 119 nucleotides
Theoretical weight: 38.32 KDa
Source organism: Trypanosoma brucei
Sequence domains: 5S ribosomal RNA
SHORT RRNA-I OF THE LARGE RIBOSOMAL SUBUNIT Chain: BE
Molecule details ›
Chain: BE
Length: 210 nucleotides
Theoretical weight: 67.23 KDa
Source organism: Trypanosoma brucei
SHORT RRNA-II OF THE LARGE RIBOSOMAL SUBUNIT Chain: BF
Molecule details ›
Chain: BF
Length: 73 nucleotides
Theoretical weight: 23.08 KDa
Source organism: Trypanosoma brucei
SHORT RRNA-III OF THE LARGE RIBOSOMAL SUBUNIT Chain: BG
Molecule details ›
Chain: BG
Length: 182 nucleotides
Theoretical weight: 58.89 KDa
Source organism: Trypanosoma brucei
Sequence domains: Eukaryotic large subunit ribosomal RNA
SHORT RRNA-IV OF THE LARGE RIBOSOMAL SUBUNIT Chain: BH
Molecule details ›
Chain: BH
Length: 135 nucleotides
Theoretical weight: 43.39 KDa
Source organism: Trypanosoma brucei
18S Ribosomal RNA Chain: AA
Molecule details ›
Chain: AA
Length: 2251 nucleotides
Theoretical weight: 724.38 KDa
Source organism: Trypanosoma brucei
Sequence domains: Eukaryotic small subunit ribosomal RNA
E-SITE TRNA Chain: AB
Molecule details ›
Chain: AB
Length: 73 nucleotides
Theoretical weight: 23.55 KDa
Source organism: Trypanosoma brucei
Sequence domains: tRNA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.57Å
Relevant EMDB volumes: EMD-2239

Quick links

Citations

18 review citations

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.
Field et al. (2017)
17 more

12 mentions without citation

Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM.
Liu et al. (2017)
11 more