› 4v8v

Electron Microscopy
20Å resolution

Structure and conformational variability of the Mycobacterium tuberculosis fatty acid synthase multienzyme complex

Released:
DOI: 10.2210/pdb4v8v/pdb
PDB entry 4v8v coloured by chain, front view.
PDB entry 4v8v coloured by chain, side view.
PDB entry 4v8v coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Ciccarelli L, Connell SR, Enderle M, Mills DJ, Vonck J, Grininger M
Structure 21 1251-7 (2013)
PMID: 23746808
Related structures: EMD-2358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TYPE-I FATTY ACID SYNTHASE Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 3089 amino acids
Theoretical weight: 329.89 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

1 bound ligand:
Ligand FMN 6 x FMN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 20Å
Relevant EMDB volumes: EMD-2358
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems.
Grininger M. (2014)
6 more

2 mentions without citation

Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM.
Bendre et al. (2021)
1 more