› 4v8w

Electron Microscopy
17.5Å resolution

Structure and conformational variability of the Mycobacterium tuberculosis fatty acid synthase multienzyme complex

Released:
DOI: 10.2210/pdb4v8w/pdb
PDB entry 4v8w coloured by chain, front view.
PDB entry 4v8w coloured by chain, side view.
PDB entry 4v8w coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
Ciccarelli L, Connell SR, Enderle M, Mills DJ, Vonck J, Grininger M
Structure 21 1251-7 (2013)
PMID: 23746808
Related structures: EMD-2357

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165269 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TYPE-I FATTY ACID SYNTHASE Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 3089 amino acids
Theoretical weight: 329.89 KDa
Source organism: Mycobacterium tuberculosis

Ligands and Environments

1 bound ligand:
Ligand FMN 6 x FMN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 17.5Å
Relevant EMDB volumes: EMD-2357

Quick links

Citations

7 review citations

Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems.
Grininger M. (2014)
6 more

3 mentions without citation

Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM.
Bendre et al. (2021)
2 more