› 4wyt

X-ray diffraction
2.6Å resolution

Crystal Structure of Scribble PDZ34 tandem at 2.6 Angstroms

Released:
DOI: 10.2210/pdb4wyt/pdb
PDB entry 4wyt coloured by chain, front view.
PDB entry 4wyt coloured by chain, side view.
PDB entry 4wyt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule.
Ren J, Feng L, Bai Y, Pei H, Yuan Z, Feng W
Biochem J 468 133-44 (2015)
PMID: 25734361

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171945 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein scribble homolog Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 22.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14160 (Residues: 992-1203; Coverage: 13%)
Gene names: CRIB1, KIAA0147, LAP4, SCRB1, SCRIB, VARTUL
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 69.14Å b: 70.85Å c: 92.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.283
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
1 more

3 mentions without citation

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.
Lim et al. (2017)
2 more