› 4x2q

X-ray diffraction
2.94Å resolution

Crystal Structure of Human Aldehyde Dehydrogenase, ALDH1a2

Released:
DOI: 10.2210/pdb4x2q/pdb
PDB entry 4x2q coloured by chain, front view.
PDB entry 4x2q coloured by chain, side view.
PDB entry 4x2q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Stenkamp RE, Le Trong I, Amory JK, Paik J, Goldstein AS

Function and Biology Details

Reaction catalysed: 
Retinal + NAD(+) + H(2)O = retinoate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinal dehydrogenase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 504 amino acids
Theoretical weight: 55.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94788 (Residues: 21-518; Coverage: 96%)
Gene names: ALDH1A2, RALDH2
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 4 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 84.597Å b: 140.508Å c: 164.452Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.268 0.266 0.313
Expression system: Escherichia coli

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