› 4x9p

X-ray diffraction
2.01Å resolution

Crystal structure of bovine Annexin A2

Released:
DOI: 10.2210/pdb4x9p/pdb
PDB entry 4x9p coloured by chain, front view.
PDB entry 4x9p coloured by chain, side view.
PDB entry 4x9p coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects.
Raddum AM, Hollås H, Shumilin IA, Henklein P, Kretsinger R, Fossen T, Vedeler A
Biochem Pharmacol 95 1-15 (2015)
PMID: 25772737

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137557 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A2 Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.99 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04272 (Residues: 1-339; Coverage: 100%)
Gene names: ANX2, ANXA2
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 48.315Å b: 63.274Å c: 117.334Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.156 0.209
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies - A review.
Al-Abd et al. (2017)
3 more

1 mention without citation

The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA.
Grindheim et al. (2023)