› 4x9z

X-ray diffraction
1.5Å resolution

Dimeric conotoxin alphaD-GeXXA

Released:
DOI: 10.2210/pdb4x9z/pdb
PDB entry 4x9z coloured by chain, front view.
PDB entry 4x9z coloured by chain, side view.
PDB entry 4x9z coloured by chain, top view.
Source organism: Conus generalis
Primary publication:
Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors.
Xu S, Zhang T, Kompella SN, Yan M, Lu A, Wang Y, Shao X, Chi C, Adams DJ, Ding J, Wang C
Sci Rep 5 14261 (2015)
PMID: 26395518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin GeXXA Chains: A, B
Molecule details ›
Chains: A, B
Length: 50 amino acids
Theoretical weight: 5.64 KDa
Source organism: Conus generalis
UniProt:
  • Canonical: A0A0A0VBX4 (Residues: 46-95; Coverage: 68%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P212121
Unit cell:
a: 25.436Å b: 42.423Å c: 83.013Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.223

Quick links

Citations

6 review citations

Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms.
Dutertre et al. (2017)
5 more

5 mentions without citation

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications.
Kasheverov et al. (2022)
4 more