› 4xaa

X-ray diffraction
2.3Å resolution

Crystal Structure of AviO1 from Streptomyces viridochromogenes Tue57

Released:
DOI: 10.2210/pdb4xaa/pdb
PDB entry 4xaa coloured by chain, front view.
PDB entry 4xaa coloured by chain, side view.
PDB entry 4xaa coloured by chain, top view.
Source organism: Streptomyces viridochromogenes Tue57
Primary publication:
Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM
Proc Natl Acad Sci U S A 112 11547-52 (2015)
PMID: 26240321

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188091 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative oxygenase Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 24.33 KDa
Source organism: Streptomyces viridochromogenes Tue57
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q93KW4 (Residues: 1-223; Coverage: 100%)
Gene names: STVIR_2892, aviO1
Sequence domains: Phytanoyl-CoA dioxygenase (PhyH)
Structure domains: q2cbj1_9rhob like domain

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21212
Unit cell:
a: 72.119Å b: 115.144Å c: 33.864Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Oxidative Cyclization in Natural Product Biosynthesis.
Tang et al. (2017)
5 more

2 mentions without citation

Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
McCulloch et al. (2015)
1 more