› 4xdx

X-ray diffraction
0.95Å resolution

The crystal structure of soluble human interleukin 8 expressed in Pichia pastoris

Released:
DOI: 10.2210/pdb4xdx/pdb
PDB entry 4xdx coloured by chain, front view.
PDB entry 4xdx coloured by chain, side view.
PDB entry 4xdx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ostrov DA, Pompeu YA, Jakoncic JJ

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IL-8(8-77) Chain: A
Molecule details ›
Chain: A
Length: 70 amino acids
Theoretical weight: 8.24 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P10145 (Residues: 30-99; Coverage: 89%)
Gene names: CXCL8, IL8
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P3121
Unit cell:
a: 40.093Å b: 40.093Å c: 89.269Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.122 0.121 0.136
Expression system: Komagataella pastoris

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