› 4xtb

X-ray diffraction
1.5Å resolution

Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter

Released:
DOI: 10.2210/pdb4xtb/pdb
PDB entry 4xtb coloured by chain, front view.
PDB entry 4xtb coloured by chain, side view.
PDB entry 4xtb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter.
Lee Y, Min CK, Kim TG, Song HK, Lim Y, Kim D, Shin K, Kang M, Kang JY, Youn HS, Lee JG, An JY, Park KR, Lim JJ, Kim JH, Kim JH, Park ZY, Kim YS, Wang J, Kim DH, Eom SH
EMBO Rep 16 1318-33 (2015)
PMID: 26341627

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185506 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium uniporter protein, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NE86 (Residues: 75-185; Coverage: 32%)
Gene names: C10orf42, CCDC109A, MCU
Sequence domains: Mitochondrial calcium uniporter

Ligands and Environments

1 bound ligand:
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P65
Unit cell:
a: 55.463Å b: 55.463Å c: 68.929Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.142 0.14 0.176
Expression system: Escherichia coli

Quick links

Citations

24 review citations

The machineries, regulation and cellular functions of mitochondrial calcium.
Giorgi et al. (2018)
23 more

7 mentions without citation

Mitochondrial Ca2+ transport in the endothelium: regulation by ions, redox signalling and mechanical forces.
Alevriadou et al. (2017)
6 more