Function and Biology Details
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Zinc finger, RanBP2-type
- Large ribosomal subunit protein uL5 domain superfamily
- Large ribosomal subunit protein uL5
- Zinc finger, RanBP2-type superfamily
- p53 negative regulator Mdm2/Mdm4
- Large ribosomal subunit protein uL5, C-terminal
- Large ribosomal subunit protein uL5, conserved site
- Large ribosomal subunit protein uL5, N-terminal
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158760 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Large ribosomal subunit protein uL5
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 20.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 178 amino acids
Theoretical weight: 20.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P62913 (Residues: 1-178; Coverage: 100%)
Sequence domains:
E3 ubiquitin-protein ligase Mdm2
Molecule details ›
Chain: B
Length: 148 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Zn-finger in Ran binding protein and others
Structure domains: Zn-finger domain of Sec23/24
Length: 148 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q00987 (Residues: 290-437; Coverage: 30%)
Sequence domains: Zn-finger in Ran binding protein and others
Structure domains: Zn-finger domain of Sec23/24
