› 4ylr

X-ray diffraction
2.55Å resolution

Tubulin Glutamylase

Released:
DOI: 10.2210/pdb4ylr/pdb
PDB entry 4ylr coloured by chain, front view.
PDB entry 4ylr coloured by chain, side view.
PDB entry 4ylr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.
Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A
Cell 161 1112-1123 (2015)
PMID: 25959773

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180600 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tubulin polyglutamylase TTLL7 Chain: A
Molecule details ›
Chain: A
Length: 487 amino acids
Theoretical weight: 57.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZT98 (Residues: 36-518; Coverage: 55%)
Gene name: TTLL7
Sequence domains: Tubulin-tyrosine ligase family

Ligands and Environments

1 bound ligand:
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2221
Unit cell:
a: 78.548Å b: 121.762Å c: 129.858Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.222 0.268
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Posttranslational Modifications of Tubulin and Cilia.
Wloga et al. (2017)
11 more

2 mentions without citation

Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns.
Natarajan et al. (2017)
1 more