Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- C-5 cytosine methyltransferase
- Bromo adjacent homology (BAH) domain
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- Bromo adjacent homology (BAH) domain superfamily
- Zinc finger, CXXC-type
- Ubiquitin carboxyl-terminal hydrolase, C-terminal
- Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
- DNA methylase, C-5 cytosine-specific, conserved site
2 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150713 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA (cytosine-5)-methyltransferase 1
Molecule details ›
Ubiquitin carboxyl-terminal hydrolase 7
Molecule details ›
Chain: C
Length: 548 amino acids
Theoretical weight: 64.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 548 amino acids
Theoretical weight: 64.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q93009 (Residues: 560-1102; Coverage: 49%)
Sequence domains:
