› 4z79

X-ray diffraction
1.54Å resolution

Leiomodin-1 Actin-Binding Site 2 (ABS2)

Released:
DOI: 10.2210/pdb4z79/pdb
PDB entry 4z79 coloured by chain, front view.
PDB entry 4z79 coloured by chain, side view.
PDB entry 4z79 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R
Nat Commun 6 8314 (2015)
PMID: 26370058

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leiomodin-1 Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 21.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29536 (Residues: 299-486; Coverage: 31%)
Gene name: LMOD1
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

3 bound ligands:
Ligand GOL 6 x GOL
Ligand CL 1 x CL
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P212121
Unit cell:
a: 49.019Å b: 52.192Å c: 75.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.156 0.177
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The WH2 Domain and Actin Nucleation: Necessary but Insufficient.
Dominguez R. (2016)
11 more

2 mentions without citation

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Boczkowska et al. (2015)
1 more