› 4z8g

X-ray diffraction
2.1Å resolution

Chimera of Tropomodulin-1 and Leiomodin-1 Actin-Binding Site 2 (TL1 ABS2)

Released:
DOI: 10.2210/pdb4z8g/pdb
PDB entry 4z8g coloured by chain, front view.
PDB entry 4z8g coloured by chain, side view.
PDB entry 4z8g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R
Nat Commun 6 8314 (2015)
PMID: 26370058

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leiomodin-1; Tropomodulin-1 Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28289 (Residues: 163-229; Coverage: 19%)
  • Canonical: P29536 (Residues: 365-486; Coverage: 20%)
Gene names: D9S57E, LMOD1, TMOD, TMOD1
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand NI 9 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P212121
Unit cell:
a: 53.468Å b: 53.936Å c: 75.604Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.254
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The WH2 Domain and Actin Nucleation: Necessary but Insufficient.
Dominguez R. (2016)
11 more

1 mention without citation

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.
Boczkowska et al. (2015)