› 4zf7

X-ray diffraction
1.89Å resolution

Crystal structure of ferret interleukin-2

Released:
DOI: 10.2210/pdb4zf7/pdb
PDB entry 4zf7 coloured by chain, front view.
PDB entry 4zf7 coloured by chain, side view.
PDB entry 4zf7 coloured by chain, top view.
Source organism: Mustela putorius furo
Primary publication:
Structural and functional characterisation of ferret interleukin-2.
Ren B, McKinstry WJ, Pham T, Newman J, Layton DS, Bean AG, Chen Z, Laurie KL, Borg K, Barr IG, Adams TE
Dev Comp Immunol 55 32-8 (2016)
PMID: 26472619

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107126 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 16.08 KDa
Source organism: Mustela putorius furo
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A3FBE6 (Residues: 21-152; Coverage: 100%)
Gene name: IL2
Sequence domains: Interleukin 2
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

4 bound ligands:
Ligand SO4 2 x SO4
Ligand PG4 2 x PG4
Ligand PEG 1 x PEG
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P3221
Unit cell:
a: 92.938Å b: 92.938Å c: 89.352Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.165 0.197
Expression system: Spodoptera frugiperda

Quick links

Citations

1 citations in other articles

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.
Newman et al. (2018)

1 mention without citation

Structural and functional characterisation of ferret interleukin-2.
Ren et al. (2016)