› 4zhh

X-ray diffraction
2.04Å resolution

Siderocalin-mediated recognition and cellular uptake of actinides

Released:
DOI: 10.2210/pdb4zhh/pdb
PDB entry 4zhh coloured by chain, front view.
PDB entry 4zhh coloured by chain, side view.
PDB entry 4zhh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Allred BE, Rupert PB, Gauny SS, An DD, Ralston CY, Sturzbecher-Hoehne M, Strong RK, Abergel RJ
Proc Natl Acad Sci U S A 112 10342-7 (2015)
PMID: 26240330

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil gelatinase-associated lipocalin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 180 amino acids
Theoretical weight: 20.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P80188 (Residues: 21-198; Coverage: 100%)
Gene names: HNL, LCN2, NGAL
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

5 bound ligands:
Ligand SM 6 x SM
Ligand 4OL 6 x 4OL
Ligand SO4 5 x SO4
Ligand GOL 5 x GOL
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 110.683Å b: 115.32Å c: 120.517Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.198
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.
Xiao et al. (2017)
4 more

1 mention without citation

Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Allred et al. (2015)