› 5a2f

X-ray diffraction
1.86Å resolution

Two membrane distal IgSF domains of CD166

Released:
DOI: 10.2210/pdb5a2f/pdb
PDB entry 5a2f coloured by chain, front view.
PDB entry 5a2f coloured by chain, side view.
PDB entry 5a2f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.
Chappell PE, Garner LI, Yan J, Metcalfe C, Hatherley D, Johnson S, Robinson CV, Lea SM, Brown MH
Structure 23 1426-1436 (2015)
PMID: 26146185

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD166 antigen Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.18 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q13740 (Residues: 1-583; Coverage: 100%)
Gene names: ALCAM, MEMD
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand EDO 16 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P43212
Unit cell:
a: 72.32Å b: 72.32Å c: 105.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.239
Expression system: Cricetulus griseus

Quick links

Citations

6 review citations

SALSA-A dance on a slippery floor with changing partners.
Reichhardt et al. (2017)
5 more

5 mentions without citation

Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.
Chappell et al. (2015)
4 more