› 5a3f

X-ray diffraction
3.7Å resolution

Crystal structure of the dynamin tetramer

Released:
DOI: 10.2210/pdb5a3f/pdb
PDB entry 5a3f coloured by chain, front view.
PDB entry 5a3f coloured by chain, side view.
PDB entry 5a3f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the dynamin tetramer.
Reubold TF, Faelber K, Plattner N, Posor Y, Ketel K, Curth U, Schlegel J, Anand R, Manstein DJ, Noé F, Haucke V, Daumke O, Eschenburg S
Nature 525 404-8 (2015)
PMID: 26302298

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194059 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dynamin-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 754 amino acids
Theoretical weight: 85.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UQ16 (Residues: 1-764; Coverage: 87%)
Gene names: DNM3, KIAA0820
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 97.696Å b: 98.002Å c: 401.524Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.278
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

20 review citations

Membrane fission by dynamin: what we know and what we need to know.
Antonny et al. (2016)
19 more

15 mentions without citation

Structural basis of mitochondrial receptor binding and constriction by DRP1.
Kalia et al. (2018)
14 more