5a7x

Electron Microscopy
17Å resolution

negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-208510 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Surface protein gp120 Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 313 amino acids
Theoretical weight: 34.84 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P35961 (Residues: 81-479; Coverage: 38%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
T-cell surface glycoprotein CD4 Chains: B, F, J
Molecule details ›
Chains: B, F, J
Length: 181 amino acids
Theoretical weight: 20.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 26-206; Coverage: 42%)
Gene name: CD4
Sequence domains:
FAB OF BROADLY NEUTRALIZING ANTIBODY 17B Chains: C, G, K
Molecule details ›
Chains: C, G, K
Length: 214 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
FAB OF BROADLY NEUTRALIZING ANTIBODY 17B Chains: D, H, L
Molecule details ›
Chains: D, H, L
Length: 229 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
FAB OF BROADLY NEUTRALIZING ANTIBODY 8ANC195 Chains: M, O, Q
Molecule details ›
Chains: M, O, Q
Length: 215 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
FAB OF BROADLY NEUTRALIZING ANTIBODY 8ANC195 Chains: N, P, R
Molecule details ›
Chains: N, P, R
Length: 244 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 17Å
Relevant EMDB volumes: EMD-3086
Expression system: Homo sapiens