› 5aas

Solution NMR

The selective autophagy receptor TAX1BP1 is required for autophagy- dependent capture of cytosolic Salmonella typhimurium

Released:
DOI: 10.2210/pdb5aas/pdb
PDB entry 5aas coloured by chain, ensemble of 20 models, front view.
PDB entry 5aas coloured by chain, ensemble of 20 models, side view.
PDB entry 5aas coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.
Tumbarello DA, Manna PT, Allen M, Bycroft M, Arden SD, Kendrick-Jones J, Buss F
PLoS Pathog 11 e1005174 (2015)
PMID: 26451915

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183212 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tax1-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86VP1 (Residues: 722-784; Coverage: 8%)
Gene names: PRO0105, T6BP, TAX1BP1
Sequence domains: Autophagy receptor zinc finger-C2H2 domain
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

46 review citations

Molecular definitions of autophagy and related processes.
Galluzzi et al. (2017)
45 more

2 mentions without citation

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.
Tumbarello et al. (2015)
1 more