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X-ray diffraction
1.74Å resolution

CRYSTAL STRUCTURE OF THE C-TERMINAL COILED-COIL DOMAIN OF CIN85 IN SPACE GROUP P321

Released:
DOI: 10.2210/pdb5abs/pdb
PDB entry 5abs coloured by chain, front view.
PDB entry 5abs coloured by chain, side view.
PDB entry 5abs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.
Kühn J, Wong LE, Pirkuliyeva S, Schulz K, Schwiegk C, Fünfgeld KG, Keppler S, Batista FD, Urlaub H, Habeck M, Becker S, Griesinger C, Wienands J
Sci Signal 9 ra66 (2016)
PMID: 27353366

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188371 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 domain-containing kinase-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96B97 (Residues: 599-662; Coverage: 10%)
Gene names: CIN85, SH3KBP1

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P321
Unit cell:
a: 40.968Å b: 40.968Å c: 90.036Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.244 0.283
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Role of Bruton's tyrosine kinase in B cells and malignancies.
Pal Singh et al. (2018)
3 more

1 mention without citation

Associations of Air Pollution and Noise with Local Brain Structure in a Cohort of Older Adults.
Nußbaum et al. (2020)