› 5ail

X-ray diffraction
1.55Å resolution

Human PARP9 2nd macrodomain

Released:
DOI: 10.2210/pdb5ail/pdb
PDB entry 5ail coloured by chain, front view.
PDB entry 5ail coloured by chain, side view.
PDB entry 5ail coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sieg C, Shrestha L, Talon R, Sorrell F, Williams E, von Delft F, Bountra C, Arrowsmith C, Edwards AM, Knapp S, Elkins JM

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184922 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 186 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IXQ6 (Residues: 310-493; Coverage: 22%)
Gene names: BAL, BAL1, PARP9
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

3 bound ligands:
Ligand EDO 6 x EDO
Ligand 15P 3 x 15P
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 58.489Å b: 74.01Å c: 94.369Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.215
Expression system: Escherichia coli BL21(DE3)

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