› 5aj1

Solution NMR

Solution Structure of the Smarc Domain

Released:
DOI: 10.2210/pdb5aj1/pdb
PDB entry 5aj1 coloured by chain, ensemble of 20 models, front view.
PDB entry 5aj1 coloured by chain, ensemble of 20 models, side view.
PDB entry 5aj1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.
Allen MD, Freund SM, Zinzalla G, Bycroft M
Structure 23 1344-9 (2015)
PMID: 26073604

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171401 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12824 (Residues: 2-113; Coverage: 29%)
Gene names: BAF47, INI1, SMARCB1, SNF5L1
Sequence domains: SWI/SNF Subunit INI1, DNA binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

The molecular pathogenesis of schwannomatosis, a paradigm for the co-involvement of multiple tumour suppressor genes in tumorigenesis.
Kehrer-Sawatzki et al. (2017)
6 more

3 mentions without citation

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.
Allen et al. (2015)
2 more