Function and Biology Details
Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138357 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Angiotensin-converting enzyme, soluble form
Molecule details ›
Chains: A, B
Length: 629 amino acids
Theoretical weight: 72.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 629 amino acids
Theoretical weight: 72.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P12821 (Residues: 30-658; Coverage: 49%)
Sequence domains: Angiotensin-converting enzyme
P3(40)
Molecule details ›
Chains: P, Q
Length: 8 amino acids
Theoretical weight: 745 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 8 amino acids
Theoretical weight: 745 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P05067 (Residues: 706-713; Coverage: 1%)
Ligands and Environments
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I03
Spacegroup:
P1
Expression systems:
- Cricetulus griseus
- Not provided
