› 5ao6

X-ray diffraction
3.36Å resolution

Endo180 D1-4, trigonal form

Released:
DOI: 10.2210/pdb5ao6/pdb
PDB entry 5ao6 coloured by chain, front view.
PDB entry 5ao6 coloured by chain, side view.
PDB entry 5ao6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4.
Paracuellos P, Briggs DC, Carafoli F, Lončar T, Hohenester E
Structure 23 2133-42 (2015)
PMID: 26481812

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193652 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type mannose receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 491 amino acids
Theoretical weight: 55.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UBG0 (Residues: 35-511; Coverage: 33%)
Gene names: CLEC13E, ENDO180, KIAA0709, MRC2, UPARAP
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P3221
Unit cell:
a: 87Å b: 87Å c: 321.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.22 0.306
Expression system: Homo sapiens

Quick links

Citations

1 review citation

uPARAP/Endo180: a multifaceted protein of mesenchymal cells.
Gucciardo et al. (2022)
10 other articles

2 mentions without citation

Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein.
Sandoval et al. (2020)
1 more