› 5ayf

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186700 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase SETD7 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 28.86 KDa
Source organism: Homo sapiens
Expression system: Cell-free synthesis
UniProt:
  • Canonical: Q8WTS6 (Residues: 111-366; Coverage: 70%)
Gene names: KIAA1717, KMT7, SET7, SET9, SETD7
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SAM 1 x SAM
Ligand C7H 1 x C7H
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21212
Unit cell:
a: 102.463Å b: 39.366Å c: 67.275Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.194 0.258
Expression system: Cell-free synthesis

Quick links

Citations

13 review citations

Inhibitors of Protein Methyltransferases and Demethylases.
Kaniskan et al. (2018)
12 more

2 mentions without citation

Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family.
Li et al. (2019)
1 more