› 5b4p

X-ray diffraction
2.4Å resolution

Complex structure of human C5a and its binding repebody

Released:
DOI: 10.2210/pdb5b4p/pdb
PDB entry 5b4p coloured by chain, front view.
PDB entry 5b4p coloured by chain, side view.
PDB entry 5b4p coloured by chain, top view.
Source organisms:
Entry authors: Kim H-S, Choi JM, Hwang DE

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133873 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
repebody Chains: A, C
Molecule details ›
Chains: A, C
Length: 261 amino acids
Theoretical weight: 29.04 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Ribonuclease Inhibitor
C5a anaphylatoxin Chains: B, D
Molecule details ›
Chains: B, D
Length: 75 amino acids
Theoretical weight: 8.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01031 (Residues: 678-751; Coverage: 5%)
Gene names: C5, CPAMD4
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)

Ligands and Environments

2 bound ligands:
Ligand 1PE 2 x 1PE
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P2221
Unit cell:
a: 55.837Å b: 87.553Å c: 188.392Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.274 0.272 0.31
Expression system: Escherichia coli

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