› 5b6n

X-ray diffraction
2.9Å resolution

Crystal structures of human peroxiredoxin 6 in sulfinic acid state

Released:
DOI: 10.2210/pdb5b6n/pdb
PDB entry 5b6n coloured by chain, front view.
PDB entry 5b6n coloured by chain, side view.
PDB entry 5b6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human peroxiredoxin 6 in different oxidation states.
Kim KH, Lee W, Kim EE
Biochem Biophys Res Commun 477 717-722 (2016)
PMID: 27353378

Function and Biology Details

Reactions catalysed: 
2 glutathione + ROOH = glutathione disulfide + H(2)O + ROH
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-6 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 224 amino acids
Theoretical weight: 25.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: P30041 (Residues: 1-224; Coverage: 100%)
Gene names: AOP2, KIAA0106, PRDX6
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CSD 6 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 94.419Å b: 106.539Å c: 167.915Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.248 0.304
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4

Quick links

Citations

7 review citations

Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling.
Fisher AB. (2017)
6 more

6 mentions without citation

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities.
Bolduc et al. (2021)
5 more