5bnq

X-ray diffraction
2.8Å resolution

Crystal structure of hRANKL-mRANK complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-127142 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 11, soluble form Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14788 (Residues: 158-317; Coverage: 51%)
Gene names: OPGL, RANKL, TNFSF11, TRANCE
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 11A Chain: R
Molecule details ›
Chain: R
Length: 216 amino acids
Theoretical weight: 24.02 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O35305 (Residues: 26-210; Coverage: 30%)
Gene names: Rank, Tnfrsf11a
Sequence domains:
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P63
Unit cell:
a: 122.188Å b: 122.188Å c: 94.473Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.171 0.203
Expression system: Escherichia coli BL21(DE3)