› 5bpq

X-ray diffraction
2.4Å resolution

Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form II

Released:
DOI: 10.2210/pdb5bpq/pdb
PDB entry 5bpq coloured by chain, front view.
PDB entry 5bpq coloured by chain, side view.
PDB entry 5bpq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY
Elife 4 (2015)
PMID: 26158506

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193934 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Frizzled-4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 149 amino acids
Theoretical weight: 16.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9ULV1 (Residues: 42-179; Coverage: 28%)
Gene name: FZD4
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

2 bound ligands:
Ligand NAG 4 x NAG
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P61
Unit cell:
a: 76.075Å b: 76.075Å c: 204.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.243
Expression system: Homo sapiens

Quick links

Citations

18 review citations

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Nusse et al. (2017)
17 more

4 mentions without citation

Assembly and architecture of the Wnt/β-catenin signalosome at the membrane.
DeBruine et al. (2017)
3 more