Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Norrin and Frizzled-4 (preferred)
PDBe Complex ID:
PDB-CPX-169450 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Norrin
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Cystine-knot domain
Structure domains: Cystine-knot cytokines
Length: 122 amino acids
Theoretical weight: 13.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q00604 (Residues: 25-133; Coverage: 100%)
Sequence domains: Cystine-knot domain
Structure domains: Cystine-knot cytokines
Norrin
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Cystine-knot domain
Structure domains: Cystine-knot cytokines
Length: 122 amino acids
Theoretical weight: 13.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q00604 (Residues: 25-133; Coverage: 100%)
Sequence domains: Cystine-knot domain
Structure domains: Cystine-knot cytokines
Frizzled-4
Molecule details ›
Chain: C
Length: 149 amino acids
Theoretical weight: 16.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain
Length: 149 amino acids
Theoretical weight: 16.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9ULV1 (Residues: 42-179; Coverage: 28%)
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain
