› 5c16

X-ray diffraction
2.07Å resolution

Myotubularin-related proetin 1

Released:
DOI: 10.2210/pdb5c16/pdb
PDB entry 5c16 coloured by chain, front view.
PDB entry 5c16 coloured by chain, side view.
PDB entry 5c16 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity.
Bong SM, Son KB, Yang SW, Park JW, Cho JW, Kim KT, Kim H, Kim SJ, Kim YJ, Lee BI
PLoS One 11 e0152611 (2016)
PMID: 27018598

Function and Biology Details

Reactions catalysed: 
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myotubularin-related protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 571 amino acids
Theoretical weight: 65.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13613 (Residues: 95-665; Coverage: 86%)
Gene name: MTMR1
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand PO4 6 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P1
Unit cell:
a: 67.219Å b: 96.587Å c: 97.581Å
α: 87.6° β: 86.07° γ: 77.33°
R-values:
R R work R free
0.223 0.22 0.274
Expression system: Escherichia coli

Quick links

Citations

2 review citations

WANTED - Dead or alive: Myotubularins, a large disease-associated protein family.
Raess et al. (2017)
1 more

1 mention without citation

Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity.
Bong et al. (2016)