5c3g

X-ray diffraction
2.45Å resolution

Crystal structure of Bcl-xl bound to BIM-MM

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-128973 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 66%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 22 amino acids
Theoretical weight: 2.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 146-166; Coverage: 11%)
Gene names: BCL2L11, BIM
Sequence domains: Bcl-x interacting, BH3 domain

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P6322
Unit cell:
a: 106.22Å b: 106.22Å c: 92.76Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.224 0.274
Expression systems:
  • Escherichia coli
  • Not provided