› 5c41

X-ray diffraction
1.95Å resolution

Crystal structure of human ribokinase in complex with AMPPCP in P21 spacegroup and with 4 protomers

Released:
DOI: 10.2210/pdb5c41/pdb
PDB entry 5c41 coloured by chain, front view.
PDB entry 5c41 coloured by chain, side view.
PDB entry 5c41 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Park J, Chakrabarti J, Singh B, Gupta RS, Junop MS

Function and Biology Details

Reaction catalysed: 
ATP + D-ribose = ADP + D-ribose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribokinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 330 amino acids
Theoretical weight: 35.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H477 (Residues: 1-322; Coverage: 100%)
Gene names: RBKS, RBSK
Sequence domains: pfkB family carbohydrate kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

3 bound ligands:
Ligand ACP 4 x ACP
Ligand NA 8 x NA
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 51.95Å b: 89.19Å c: 144.4Å
α: 90° β: 98.16° γ: 90°
R-values:
R R work R free
0.174 0.172 0.207
Expression system: Escherichia coli BL21(DE3)

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