Function and Biology Details
Reactions catalysed:
GTP + H(2)O = GDP + phosphate
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Small GTPase
- Phosphatidylinositol 3/4-kinase, conserved site
- P-loop containing nucleoside triphosphate hydrolase
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- Protein kinase-like domain superfamily
- Phosphatidylinositol kinase
- Phosphoinositide 3-kinase, accessory (PIK) domain
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158626 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ras-related protein Rab-11A
Molecule details ›
Chain: B
Length: 219 amino acids
Theoretical weight: 24.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Length: 219 amino acids
Theoretical weight: 24.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P62491 (Residues: 1-216; Coverage: 100%)
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Phosphatidylinositol 4-kinase beta
Molecule details ›
Chain: E
Length: 529 amino acids
Theoretical weight: 60.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 529 amino acids
Theoretical weight: 60.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9UBF8 (Residues: 121-799; Coverage: 64%)
Sequence domains:
